“The Missouri Compromise!”

Maine statehood

“Congress passed the Kansas-Nebraska Act, overturning the Missouri Compromise and permitting the spread of slavery to the West.” HCR wrote that the repercussions of that 1854 action included the creation of the Republican Party by 1856. When he ran for President in 1860, Lincoln picked Hannibal Hamlin of Maine to be his running mate.

So, the Missouri Compromise was the beginning of much anti-slavery fervor, which helped define the issue before the Civil War. 
Ramblin' with Roger
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